Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10904338 | Experimental Cell Research | 2013 | 9 Pages |
Abstract
⺠A novel FGF8b-binding peptide P12 was isolated from a phage display library. ⺠The mechanisms for P12 peptide inhibiting cell proliferation were proposed. ⺠P12 caused cell cycle arrest at G0/G1 phase via suppression of Cyclin D1 and PCNA. ⺠P12 suppressed FGF8b-induced activations of Akt and MAP kinases. ⺠P12 acting as an FGF8b antagonist may have therapeutic potential in prostate cancer.
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Authors
Wenhui Wang, Xilei Chen, Tao Li, Yanmei Li, Ruixue Wang, Dan He, Wu Luo, Xiaokun Li, Xiaoping Wu,