Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects

Article ID	Journal	Published Year	Pages	File Type
10904359	Experimental Cell Research	2013	9 Pages	PDF

Abstract

âº Connexin43 phosphorylation plays a role in laminopathy-associated conduction defects. âº Loss of A-type lamin activity results in release of pERK1/2 from the nucleus. âº Increased cytoplasmic localization of pERK1/2 acts to phosphorylate S279/282 of Cx43. âº Phosphorylation of S279/282 on Cx43 decreases gap junction activity in cell culture. âº Mice lacking A-type lamins have increased phosphorylation on S279/282 of Cx43.

Keywords

MEF ERK EDMD LGMD Connexin43 CX43 MAPK pERK1/2 Emery–Dreifuss muscular dystrophy Limb-girdle muscular dystrophy gap junction phospho-ERK nuclear lamins mouse embryonic fibroblast Cardiac conduction mitogen-activated protein kinase PERK extracellular signal-regulated kinase