| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10904367 | Experimental Cell Research | 2013 | 12 Pages |
Abstract
⺠Human organotypic and keratinocyte 'diabetic' skin models were used to demonstrate the ability of Gap27 to improve scrape-wound closure. ⺠Gap27 enhanced scrape-wound closure by reducing Cx43-mediated communication, whereas IGFBP-5 retarded cell migration. ⺠IGF-I and IGFBP-5 did not affect connexin-mediated pathways. ⺠Gap27 can override altered glucose, insulin, IGF-I, and IGFBP-5 in 'diabetic' skin models and thus has therapeutic potential.
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Authors
Catherine S. Wright, Rebecca F. Berends, David J. Flint, Patricia E.M. Martin,