| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10904376 | Experimental Cell Research | 2013 | 11 Pages |
Abstract
⺠Apolipoprotein E (ApoE) significantly inhibited osteoclast differentiation and activation of NF-κB. ⺠ApoE decreased the induction of osteoclast marker genes such as c-Fos, NFATc1, TRAP, DC-STAMP and Cathepsin K. ⺠ApoE reduced number of TRAP-positive multinuclear cells. ⺠Exogenous ApoE inhibits osteoclast formation by reduction of crucial factor of osteoclast differentiation. ⺠knock-down of ApoE promoted the RANKL-mediated induction of osteoclast differentiation.
Keywords
Atp6v0d2RANKLTRAPc-fosM-CSFMNCsNF-κBNFATc1OSCARDC-STAMPBMMsApoeapolipoprotein Etartrate-resistant acid phosphataseOsteoclast differentiationMultinucleated cellsmacrophage colony-stimulating factorBone marrow-derived macrophagesdendritic cell-specific transmembrane proteinosteoclast-associated receptorreceptor activator of NF-κB ligand
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Authors
Woo-Shin Kim, Hyung Joon Kim, Zang Hee Lee, Youngkyun Lee, Hong-Hee Kim,