| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10904377 | Experimental Cell Research | 2013 | 8 Pages |
Abstract
⺠Calcineurin regulates MEF2 activity in striated muscle. ⺠mAKAP is a calcineurin scaffold in striated muscle. ⺠The mAKAP/calcineurin interaction can be disrupted using a competitive binding peptide. ⺠Disruption of the interaction prevents differentiation-induced MEF2 gene transcription in C2C12 cells. ⺠Disruption of the interaction also prevents induction of cardiac hypertrophy in neonatal cardiac myocytes.
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Authors
Jinliang Li, Maximilian A.X. Vargas, Michael S. Kapiloff, Kimberly L. Dodge-Kafka,