| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10904385 | Experimental Cell Research | 2013 | 8 Pages |
Abstract
⺠We generated human Down syndrome iPS cells from Trisomy 21 amniotic fluid cells. ⺠We modeled neurogenesis impairment by neuronal progenitor cell from T21 iPS cells. ⺠In T21-NPCs, APP levels were increased, and MeCP2 levels are decreased. ⺠In T21-NPCs, the levels of 5 miRNAs located on chromosome 21 were increased. ⺠T21-NPCs exhibited a developmentally regulated defect in neurogenesis.
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Authors
Huai-En Lu, Yao-Chen Yang, Sheng-Mei Chen, Hong-Lin Su, Pai-Cheng Huang, Ming-Song Tsai, Tzu-Hao Wang, Ching-Ping Tseng, Shiaw-Min Hwang,