Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFÎ±- and NK cytotoxicity

Article ID	Journal	Published Year	Pages	File Type
10904386	Experimental Cell Research	2013	11 Pages	PDF

Abstract

âº STAT3 silencing is negligent for basal lung cancer cell viability and proliferation. âº STAT3 depletion sensitizes lung cancer cells to DNA damaging chemotherapeutics. âº STAT3 depletion has no effect on susceptibility to extrinsic apoptosis inducers. âº Increased pro-survival NFÎºB activity may compensate for STAT3 depletion.

Keywords

STAT3 TNFα CTL NK cytotoxicity natural killer NFκB Rb, retinoblastoma Small interfering RNA shRNA, short hairpin RNA siRNA BrdU bromodeoxyuridine tumor necrosis factor α cytotoxic T lymphocyte signal transducer and activator of transcription 3