| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10904389 | Experimental Cell Research | 2013 | 10 Pages |
Abstract
⺠DNA-damaging effects of bile pigments have been rarely investigated. ⺠Thus, eight tetrapyrroles were tested for DNA-damaging effects in the comet assay. ⺠To assess DNA damage, cancer cells were used, and flow cytometry parameters were measured. ⺠Especially protoporphyrin, urobilin and stercobilin increased DNA strand breaks significantly. ⺠Mechanisms could include oxidative stress, cell cycle arrest and apoptosis.
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Authors
Christine Mölzer, Barbara Pfleger, Elisabeth Putz, Antonia RoÃmann, Ursula Schwarz, Marlies Wallner, Andrew C. Bulmer, Karl-Heinz Wagner,