Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10904433 | Experimental Cell Research | 2012 | 12 Pages |
Abstract
⺠ILK deletion results in decreased HGF expression and delayed scratch wound repair. ⺠PI3K/ILK/AKT pathway signals through HGF to regulate wound healing. ⺠An ILK-dependent increase in HGF expression is responsible for wound healing in vivo. ⺠ILK-KO mice are used to confirm the requirement for ILK function in wound healing. ⺠Human HGF treatment restores delayed wound closure in vitro and in vivo.
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Authors
Isabel Serrano, Maria L. DÃez-Marqués, Manuel RodrÃguez-Puyol, Inmaculada Herrero-Fresneda, Raimundo GarcÃa del Moral, Shoukat Dedhar, Maria P. Ruiz-Torres, Diego RodrÃguez-Puyol,