Article ID Journal Published Year Pages File Type
10904433 Experimental Cell Research 2012 12 Pages PDF
Abstract
► ILK deletion results in decreased HGF expression and delayed scratch wound repair. ► PI3K/ILK/AKT pathway signals through HGF to regulate wound healing. ► An ILK-dependent increase in HGF expression is responsible for wound healing in vivo. ► ILK-KO mice are used to confirm the requirement for ILK function in wound healing. ► Human HGF treatment restores delayed wound closure in vitro and in vivo.
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