Article ID Journal Published Year Pages File Type
10904436 Experimental Cell Research 2012 8 Pages PDF
Abstract
PPARγ's role on 1α,25-dihydroxyvitamin D3 transcriptional activity is examined. ► PPARγ physically binds to VDR and inhibits 1α,25-dihydroxyvitamin D3 action. ► PPARγ's hinge and ligand binding domains are important for this inhibitory effect. ► PPARγ competes with VDR for the availability of their binding partner, RXRα.
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