Article ID Journal Published Year Pages File Type
10904445 Experimental Cell Research 2012 7 Pages PDF
Abstract
►S1P induces αvβ6-mediated TGF-β activation through Rho Kinase. ►Cell contraction regulates S1P and LPA induced αvβ6-mediated TGF-β activation. ►S1P and LPA induced αvβ6-mediated TGF-β activation requires cellular tension. ►Increased tension in epithelial cells results from cortical actin.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Preview
Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin αvβ6-dependent physical force
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