Article ID Journal Published Year Pages File Type
10904448 Experimental Cell Research 2012 9 Pages PDF
Abstract
► Corticotropin releasing hormone (CRH) decreases hippocampal neuron cell viability in vitro in a concentration- and time-dependent manner. ► CRH receptor 1 (CRHR1) participates in CRH-induced neuron apoptosis. ► Endoplasmic reticulum (ER) stress, through activating the IRE1/ASK1/JNK cascade, plays an important role in CRH-induced neuron apoptosis.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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Endoplasmic reticulum stress contributes to CRH-induced hippocampal neuron apoptosis
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