Article ID Journal Published Year Pages File Type
10904486 Experimental Cell Research 2012 9 Pages PDF
Abstract
► We identified inhibitory factor of cystogenesis secreted by kidney epithelial cells. ► TGFβ is secreted as a latent inhibitory factor of cystogenesis. ► TGFβ2 is the major endogenous TGFβ isoform secreted by renal epithelial cells. ► TGFβ activity possibly limits cystogenesis in ADPKD.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Preview
Transforming growth factor-β inhibits cystogenesis in human autosomal dominant polycystic kidney epithelial cells
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