| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10904487 | Experimental Cell Research | 2012 | 11 Pages |
Abstract
MMPs-1, 3 and TIMPs-1, 3 are produced in the PDL fibroblasts, and their expression might be regulated by inflammatory cytokines, including IL1-β produced by SCC-25 cells. The expression of TIMP-1 and TIMP-3 is 20-70-times higher than that of MMPs-1 and 3. The gene expression of MMP-1; 2, TIMP-1 and TIMP-3 was reduced by dexamethasone (DEX) (B).170
Keywords
ECMintratumoral microvessel densityLTBP-1PDLHNSCCCAFsMT1-MMPCOX-2OSCCDEXTGF-β1FBSinterleukinMatrix remodelingTransforming growth factor-β1EMTDexamethasoneTIMPfoetal bovine serumCarcinoma-associated fibroblastsFibronectinExtracellular matrixmatrix metalloproteinaseMetastasisMembrane-type 1 matrix metalloproteinaseTissue inhibitor of metalloproteinasesprostaglandin-endoperoxide synthase 2oral squamous cell carcinomaHead and neck squamous cell carcinomaepithelial-to-mesenchymal transition
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Authors
Alexandra Fullár, Ilona Kovalszky, Mario Bitsche, Angela Romani, Volker Hans Schartinger, Georg Mathias Sprinzl, Herbert Riechelmann, József Dudás,