| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10904489 | Experimental Cell Research | 2012 | 12 Pages |
Abstract
⺠Fibroblasts cultured in stiff versus compliant 3-D collagen lattices show reduced MMP-2 levels ⺠Promoting contractile protein expression decreases MMP-2 expression ⺠Factors that promote actin disassembly block the suppression of MMP-2 expression ⺠TGF-β suppresses MMP-2 through multiple mechanisms ⺠MRTF-A and MRTF-B suppress MMP-2 expression indirectly
Keywords
ET-1TGF-βLatrunculin BRDFsMRTFSM α-actinVSMCPDGFS1PECMGPCRIGF-ISRFMMP-2MMPDMEMGAPDHG-protein-coupled receptorDulbecco's modified Eagle's mediumSphingosine-1-phosphateendothelinContractilitytransforming growth factor-βTIMPVascular smooth muscle cellInsulin-like growth factor-ISmooth muscle α-actinplatelet-derived growth factorserum response factorFibroblastExtracellular matrixmatrix metalloproteinaseTissue inhibitor of metalloproteinasesMyofibroblastglyceraldehyde 3-phosphate dehydrogenase
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Authors
Eric W. Howard, Beverly J. Crider, Dawn L. Updike, Elizabeth C. Bullen, Eileen E. Parks, Carol J. Haaksma, David M. Sherry, James J. Tomasek,