Article ID Journal Published Year Pages File Type
10904490 Experimental Cell Research 2012 10 Pages PDF
Abstract
► We designed and synthesized novel hypoxic cytoxin, TX-2098. ► TX-2098 inhibited the proliferation of human pancreatic cancer cells than TPZ. ► TX-2098 reduced VEGF protein level than TPZ. ► TX-2098 inhibited mRNA expression of VEGF, GLUT1 and Aldolase A, not HIF-1α. ► TX-2098 improved the survival in orthotopic SUIT-2 xenograft model.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Preview
The novel hypoxic cytotoxin, TX-2098 has antitumor effect in pancreatic cancer; possible mechanism through inhibiting VEGF and hypoxia inducible factor-1α targeted gene expression
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