The proteasome inhibitor MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and neck squamous cell carcinoma cells

Article ID	Journal	Published Year	Pages	File Type
10904491	Experimental Cell Research	2012	13 Pages	PDF

Abstract

âº MG132 sensitizes HNSCC cells to TRAIL-/AY4-mediated apoptotic cell death. âº MG132 potentiates TRAIL receptor-induced apoptosis by stabilizing tBid and Bik. âº Bak is constrained by Mcl-1 and Bcl-XL, but not by Bcl-2, in HNSCC cells. âº Bax did not interact with Mcl-1, Bcl-XL, or Bcl-2 in HNSCC cells. âº tBid plays a major role in Bax activation, and Bik indirectly activates Bak.

Keywords

mAb Bcl-2 protein family HNSCC TRAIL receptors mitochondrial outer membrane permeabilization Monoclonal antibody Apoptosis TRAIL tumor necrosis factor-related apoptosis inducing ligand MOMP Proteasome inhibitor Head and neck squamous cell carcinoma death receptor