Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10904517 | Experimental Cell Research | 2011 | 8 Pages |
Abstract
SCC-25 cells produce active, processed IL1-β. PDL fibroblasts possess receptor for IL1-β, and its expression is increased 4.56-times in the presence of SCC-25 tumor cells. IL1-β receptor expression in fibroblasts, especially in CAFs represents a major option in coordination of fibroblast and tumor behavior. A key event in IL1-β signaling, the phosphorylation of IRAK1, occurred in co-cultured fibroblasts, which has lead to nuclear translocation of NFκBα, and finally to induction of several genes, including BDNF, IRF1, IL-6 and COX-2. The most enhanced induction was found for IL-6 and COX-2.71
Keywords
PAI1HNSCCCAFsIL-6SDF1DEXCOX-2IRF1IL1-βTrkBBDNFinterleukin-6 (IL-6)interleukin-6Interleukin-1 betatumor necrosis factor alphaEMTDexamethasoneInterferon regulatory factor 1Stromal-derived factor 1IRAK-1Brain-derived neurotrophic factorTNF-αnuclear factor kappa betaPeriodontal ligament fibroblastsCarcinoma-associated fibroblastsprostaglandin-endoperoxide synthase 2Head and neck squamous cell carcinomaInterleukin-1 receptor-associated kinase-1Epithelial–mesenchymal transition
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
József Dudás, Alexandra Fullár, Mario Bitsche, Volker Schartinger, Ilona Kovalszky, Georg Mathias Sprinzl, Herbert Riechelmann,