Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10905089 | Experimental Cell Research | 2005 | 15 Pages |
Abstract
The pRb/E2F and Wnt/β-catenin pathways are two of the most frequently deregulated pathways in human cancers. In this study, we show that E2F1 up-regulates the expression of axin2. Further, we show that axin2 can repress Wnt signalling leading to reduced cell growth and increased cell death. This represents cross-talk between major pathways involved in the formation of tumours. We use our data to suggest a novel mechanism for tumour suppression.
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Thomas A. Hughes, Hugh J.M. Brady,