| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10905757 | Experimental Cell Research | 2005 | 12 Pages |
Abstract
Together with previous findings, these data suggest that the production of GCP-2 by endothelial cells within the tumor can contribute to tumor development through neovascularization due to endothelial cell chemotaxis and to tumor cell invasion and metastasis by attracting and activating neutrophils loaded with proteases that promote matrix degradation.
Keywords
GCP-2hMVECchemotactic indexIFN-γb-FGFConcanavalin AELRENA-78Granulocyte chemotactic protein-2dsRNALPSConAPBSStaphylococcus enterotoxin AMCP-1BSAPMANBT/BCIPdouble-stranded RNAbovine serum albuminAngiogenesisinterferon-γinterleukinInterleukin-8TumorGastrointestinal stromal tumortumor necrosis factor-αstandard error of the meanSeaGastrointestinalEndothelial cellshuman dermal microvascular endothelial cellsCytokineVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)basic fibroblast growth factorTNF-αphorbol myristate acetatelipopolysaccharidePhosphate-buffered salineSEMGistNeutrophiliaSynergyMonocyte chemotactic protein-1ChemotaxisChemokine
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Authors
Klara Gijsbers, Mieke Gouwy, Sofie Struyf, Anja Wuyts, Paul Proost, Ghislain Opdenakker, Freddy Penninckx, Nadine Ectors, Karel Geboes, Jo Van Damme,