| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10907691 | Experimental Hematology | 2005 | 9 Pages |
Abstract
We propose that decreased internalization of WHIM-associated mutated CXCR4 leads to prolongation/enhancement of signaling in response to SDF1 and that this may provide the biochemical basis for the autosomal dominant abnormalities of cell trafficking and function associated with WHIM syndrome.
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Authors
Toshinao Kawai, Uimook Choi, Narda L. Whiting-Theobald, Gilda F. Linton, Sebastian Brenner, Joan M.G. Sechler, Philip M. Murphy, Harry L. Malech,