| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10907693 | Experimental Hematology | 2005 | 7 Pages |
Abstract
Similar to what has been described in adults, most children lack memory B cells and produce low amounts of Ig. However, the number of B cells, as well as their function, gradually recovered over time and the spread of data we observed suggests that the reimmunization schedule should be individualized for each patient. It remains to be defined in a prospective clinical study the time point at which a patient should start reimmunization. A reasonable hypothesis to be explored is the time point at which a percentage of memory B cells greater than the 5th percentile of normal controls is reached.
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Authors
Maria Antonietta Avanzini, Franco Locatelli, Conceicao Dos Santos, Rita Maccario, Elisa Lenta, Mara Oliveri, Sebastian Giebel, Piero De Stefano, Francesca Rossi, Giovanna Giorgiani, Giovanni Amendola, Stefania Telli, Massimo Marconi,