Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells

These results suggest that the two endothelial selectins, E-selectin and P-selectin, have very different effects on HPC. E-selectin accelerates the differentiation of maturing HPC towards granulocyte and monocyte lineages while maintaining the production of more immature CFU-S12 in ex vivo liquid suspension culture. In marked contrast, P-selectin delays the differentiation of Lin−Sca-1+c-kit+ cells, allowing enhanced ex vivo expansion of CFC and CFU-S12 but not HSCs.