| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10907778 | Experimental Hematology | 2005 | 10 Pages |
Abstract
IL-12 produced by AML-DCs plays a critical role in counteracting the inhibitory activity of LCs on T-cell function. IL-12 gene can be successfully expressed into AML-DCs defective in endogenous IL-12 production by using a novel nonviral method that does not modify their phenotypical, cytogenetic, and functional features. Genetically modified AML-DCs restore a near normal T-cell function.
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Authors
Antonio Curti, Simona Pandolfi, Michela Aluigi, Alessandro Isidori, Isabella Alessandrini, Claudia Chiodoni, Nicoletta Testoni, Mario P. Colombo, Michele Baccarani, Roberto M. Lemoli,