Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10908023 | Experimental Hematology | 2005 | 6 Pages |
Abstract
These findings suggest that induction of tumor-lytic hTERT-specific T cells in vivo by vaccination does not result in a detectable decline in hematopoietic potential despite the expression of hTERT and major histocompatibility complex class I in bone marrow progenitors and stem cells. Thus, even for self-antigens such as telomerase, tumor immunity does not necessarily involve autoimmunity in normal tissues that share the target.
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Authors
Gwenn-aël H. Danet-Desnoyers, Jennifer L. Luongo, Dominique A. Bonnet, Susan M. Domchek, Robert H. Vonderheide,