| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10908088 | Experimental Hematology | 2005 | 11 Pages |
Abstract
N-RasL61 transformed cells lack a G0-G1 arrest upon TGF-β treatment due to absence of p27. p27 is degraded through a MapK-, and SKP2-dependent pathway. Overexpression of p27 results in restoration of cell-cycle arrest upon TGF-β treatment.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Hein Schepers, Albertus T.J. Wierenga, Bart J.L. Eggen, Edo Vellenga,