Article ID Journal Published Year Pages File Type
10908092 Experimental Hematology 2005 9 Pages PDF
Abstract
Using chronic myeloid leukemia as a model, we show that PgP-mediated resistance to imatinib and anthracyclines can be durably reversed by nonviral, transposon-based knockdown of PgP in malignant cells.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Preview
RNAi-mediated knockdown of P-glycoprotein using a transposon-based vector system durably restores imatinib sensitivity in imatinib-resistant CML cell lines
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