Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10908614 | Leukemia Research | 2015 | 16 Pages |
Abstract
One hundred forty-six CMML patients diagnosed between 1998 and 2014 were retrospectively analyzed. Univariate analysis was performed to assess prognostic impact on overall survival (OS) and leukemia-free survival (LFS) of the variables composing the scores and all items showed prognostic value on OS with the exception of the presence of circulating immature myeloid cells. Regarding LFS, only CPSS variables, bone marrow blast â¥10% and an absolute monocyte count >10 Ã 109/L had an impact. When the scores were applied, all showed an impact on OS and retained their significance in multivariate analysis. By using ROC curves and C-index, CPSS showed a slightly better predictive value for mortality and leukemia transformation. Variables composing the three indexes were compared in multivariate analysis and only CPSS parameters and platelets < 100 Ã 109/L retained their significance. Based on these findings, by adding platelet count to CPSS, a new score was implemented (CPSS-P) showing the best risk prediction capability in our series. This study reinforces the validity of the tested scores.
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Authors
Xavier Calvo, Meritxell Nomdedeu, Rodrigo Santacruz, Núria MartÃnez, Dolors Costa, Arturo Pereira, Natalia Estrada, Blanca Xicoy, Jordi Esteve, Benet Nomdedeu,