Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10908634 | Leukemia Research | 2015 | 7 Pages |
Abstract
Taken together our findings suggest that the development of the del (5q) clone is associated with accelerated telomere shortening at diagnosis. However, upon induction of CCR and reoccurrence of normal hematopoiesis, the lack of a persistent TL deficit argues against telomere-mediated genetic instability neither as a disease-promoting event of del (5q) MDS nor for lenalidomide mediated development of secondary primary malignancies of the hematopoietic system in responding patients.
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Authors
Fabian Beier, Behzad Kharabi Masouleh, Guntram Buesche, Monica S. Ventura Ferreira, Rebekka K. Schneider, Patrick Ziegler, Stefan Wilop, Lucia Vankann, Norbert Gattermann, Uwe Platzbecker, Aristoteles Giagounidis, Katharina S. Götze, Florian Nolte,