LIFRα-CT3 induces differentiation of a human acute myelogenous leukemia cell line HL-60 by suppressing miR-155 expression through the JAK/STAT Pathway

- TAT-CT3 fusion protein induced myeloid differentiation in human leukemia HL-60 cells.
- TAT-CT3 induced a rapid elevation of STAT3 phosphorylation.
- TAT-CT3 suppressed the transcription of miR-155 and induced the elevation of SOCS-1.
- TAT-CT3 results in a long-term decrease of STAT3 phosphorylation.
- TAT-CT3 may be a potential therapeutic target for future acute myelogenous leukemia therapy.