Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10908755 | Leukemia Research | 2014 | 5 Pages |
Abstract
Outcome of patients with myelodysplastic syndrome after azacitidine failure is poor. In this population, we combined cytarabine (10-20Â mg/m2/day 14 days) with vorinostat (400Â mg/day) for escalating durations (7 days, 10 days and 14 days), and starting on day 1 (concomitant arm) or on day 14 (sequential arm) following a 3Â +Â 3 phase I design. 40 patients were treated. Dose limiting toxicities were all seen in sequential arm. The overall response rate was 15% with 4 responses in concomitant arm (ORRÂ =Â 25%). We conclude that this combination is tolerable and concomitant administration might be less toxic and have better therapeutic effect (clinicaltrials.gov NCT00776503).
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Authors
Thomas Prebet, Thorsten Braun, Odile Beyne-Rauzy, Francois Dreyfus, Aspasia Stammatoullas, Eric Wattel, Shanti Ame, Emmanuel Raffoux, Jacques Delaunay, Aude Charbonnier, Lionel Adès, Pierre Fenaux, Norbert Vey,