Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10908765 | Leukemia Research | 2014 | 4 Pages |
Abstract
Primary myelofibrosis (PMF) is myeloproliferative neoplasm whose diagnosis is based on a combination of clinical and pathology criteria. We evaluated 560 consecutive patients who were diagnosed with PMF upon a referral to our center and evaluated the frequency of and reasons for diagnostic discordance. Discordance in the diagnosis was found in 70 (12.5%) patients. Discordant cases had a significantly lower grade of bone marrow fibrosis (grade 0-1), more likely to be JAK2V617F-mutation negative, and have no peripheral blood blasts, possibly explaining the difficulty in making a proper diagnosis and underscoring the need for a complete evaluation at a tertiary center.
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Authors
Cecilia Arana Yi, Ghayathri Jeyakumar, Pedro Medina, Jorge Cortes, Sherry Pierce, Carlos Bueso-Ramos, Hagop Kantarjian, Srdan Verstovsek,