Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10908812 | Leukemia Research | 2014 | 7 Pages |
Abstract
Total body irradiation (TBI) has traditionally been used in the conditioning regimen for allogenetic hematopoietic stem cell transplantation (alloHCT) from an unrelated donor (u-HCT). However, patients are increasingly receiving a fludarabine-based conditioning regimen without TBI, as it seemed less toxic than TBI. We need to know the clinical results of non-TBI u-HCT treatments. We retrospectively investigated the clinical outcomes of allogenetic hematopoietic cell transplantation (alloHCT) from an unrelated donor without TBI (non-TBI u-HCT) and compared the clinical outcomes of fludarabine-based (FLU group) and cyclophosphamide-ATG (Cy-ATG group) conditioning regimens. Sixty-one patients received the non-TBI conditioning regimen for u-HCT (32 in the FLU group and 29 in the Cy-ATG group). The cumulative incidence of neutrophil engraftment at 30 days, platelet > 20 K/μL at 30 days, acute graft-versus host disease (aGvHD) at 100 days, and chronic GvHD (cGvHD) at 2 years were 87.01%, 65.57%, 35.20%, and 26.64%, respectively. However, transplantation outcomes and overall survival rates did not differ between the FLU and Cy-ATG groups. Only infused CD34+ cells >3 Ã 106 kgâ1 was identified as a favorable factor for survival in the multivariate analysis. In conclusion, non-TBI u-HCT was feasible and there was no difference between the FLU and Cy-ATG groups in terms of transplantation outcomes.
Keywords
ANCaGVHDanti-thymocyte globulincGVHDSOSATGMSDPRCALGTBIISTTotal body irradiationMatched sibling donorDiagnosisAbsolute neutrophil countHepatic sinusoidal obstruction syndromeCyclophosphamideanti-lymphocyte globulinbone marrowplatelet concentrateAllogeneic hematopoietic stem cell transplantationaplastic anemia
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Authors
Hawk Kim, Kyoo-Hyung Lee, Inho Kim, Sang Kyun Sohn, Chul Won Jung, Young Don Joo, Sung-Hyun Kim, Byung Soo Kim, Jung Hye Choi, Jae-Yong Kwak, Min Kyoung Kim, Sung Hwa Bae, Ho Jin Shin, Jong-Ho Won, Won Sik Lee, Sukjoong Oh, Hyo Jung Kim, Jae-Hoo Park,