Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10908838 | Leukemia Research | 2014 | 4 Pages |
Abstract
The polymorphism of 14-bp tandem repeat sequence located in the ASNS gene probably acts as a transcriptional enhancer element and leads to higher expression of the gene in carriers of more than 2 repeats (>R2). We searched for an association with disease outcome in 264 children with ALL. A multivariate proportional hazard regression model adjusted for age at diagnosis (HR (95%CI)Â =Â 1.05 (1.04-1.09)) and high-risk group (HR(95%CI)Â =Â 3.47 (1.74-6.88)) revealed that R3 carriers with a poor response at day 15 had an increased risk of events, HR (95%CI)Â =Â 2.72 (1.06-6.96). These results suggest a conditional interaction between the ASNS polymorphism and an early response to chemotherapy among pediatric patients with ALL.
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Authors
Agata Pastorczak, Wojciech Fendler, Beata Zalewska-Szewczyk, Patryk Górniak, Monika Lejman, Joanna TreliÅska, Justyna Walenciak, Jerzy Kowalczyk, Tomasz Szczepanski, Wojciech Mlynarski,