Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10908905 | Leukemia Research | 2013 | 7 Pages |
Abstract
Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n = 109), AML (n = 47) and in controls (n = 24). TL was lower in MDS patients than in controls (p < 0.001) and higher in L-MDS (low, intermediate-1 IPSS, p < 0.01) respect H-MDS (high, intermediate-2 IPSS, p < 0.01) patients. Mad-1 expression was higher in MDS patients than in controls (p < 0.01), c-myc expression was highest in AML and in H-MDS patients. Our results show that the telomere dynamics might be useful for stratifying patients according to a risk scoring system.
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Authors
Antonella Poloni, Federica Serrani, Eleonora Berardinelli, Giulia Maurizi, Marianna Mariani, Benedetta Costantini, Silvia Trappolini, Stefania Mancini, Attilio Olivieri, Pietro Leoni,