Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10908929 | Leukemia Research | 2014 | 9 Pages |
Abstract
β-Catenin is a key regulator of leukemia stem cell maintenance and drug resistance. Herein, we investigated the protective effects of the stromal cell-mediated VE-cadherin-β-catenin signal on Ph+ leukemia cells during imatinib treatment. We found stromal cells could desensitize imatinib and up-regulate VE-cadherin expression on Ph+ leukemia cells (K562 and SUP-B15 cells), which further stabilized and activated β-catenin. Knockdown of VE-cadherin with shRNA diminished the β-catenin protein and partly resensitized Ph+ leukemia cells to imatinib despite the presence of stromal cells, suggesting VE-cadherin is a potential target in the treatment of Ph+ leukemia.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Chong Chen, Huan-Xin Zhang, Man Wang, Xu-Guang Song, Jiang Cao, Lin Wang, Jian-Lin Qiao, Xiao-Yun Lu, Zheng-Xiang Han, Ping Zhu, Bin Pan, Qing-Yun Wu, Kai Zhao, Zhi-Ling Yan, Zhen-Yu Li, Ling-Yu Zeng, Kai-Lin Xu,