Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10908988 | Leukemia Research | 2014 | 9 Pages |
Abstract
The role of leukapheresis and low-dose chemotherapy is unclear in decreasing early mortality in acute myeloid leukemia (AML) patients with hyperleukocytosis. This systematic review was conducted to describe early mortality (deaths during first induction) in patients with AML with an initial white blood count â¥Â 100 Ã 109 Lâ1 stratified by the approach to leukapheresis and hydroxyurea/low-dose chemotherapy. Twenty-one studies were included. Weighted mean early deaths rate (20 studies, 1354 patients) was 20.1% (95% confidence interval 15.0-25.1). Neither leukapheresis strategy (p = 0.67) nor hydroxyurea/low-dose chemotherapy (p = 0.23) influenced the early death rate. Early mortality related to hyperleukocytosis in AML is not influenced by universal or selected use of leukapheresis or hydroxyurea/low-dose chemotherapy.
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Authors
Sapna Oberoi, Thomas Lehrnbecher, Bob Phillips, Johann Hitzler, Marie-Chantal Ethier, Joseph Beyene, Lillian Sung,