Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909013 | Leukemia Research | 2013 | 6 Pages |
Abstract
Musashi-2 (MSI2) expression of 116 adult B-cells acute lymphoblastic leukemia (B-ALL) patients was measured by real-time PCR. Kaplan-Meier analysis showed that patients with high MSI2 expression had inferior overall survival (OS) (PÂ =Â 0.004), event free survival (EFS) (PÂ =Â 0.001) and relapse free survival (RFS) (PÂ =Â 0.018) in BCR-ABL-negative B-ALL. Multivariate models revealed that, besides WBC more than 30Â ÃÂ 109/L and IK6 variant of IKZF1, high MSI2 expression was also an independent prognostic factor for adult BCR-ABL-negative B-ALL. Our data suggest that high MSI2 expression could indicate poor prognosis and facilitate risk and treatment stratification in adult BCR-ABL-negative B-ALL.
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Authors
Qitian Mu, Yungui Wang, Bing Chen, Wenbin Qian, Haitao Meng, Hongyan Tong, Feifei Chen, Qiuling Ma, Wanmao Ni, Saijuan Chen, Jie Jin,