| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10909042 | Leukemia Research | 2013 | 7 Pages |
Abstract
Obesity is associated with an increased risk of acute lymphoblastic leukemia (ALL) relapse. Using mouse and cell co-culture models, we investigated whether adipose tissue attracts ALL to a protective microenvironment. Syngeneically implanted ALL cells migrated into adipose tissue within ten days. In vitro, murine ALL cells migrated towards adipose tissue explants and 3T3-L1 adipocytes. Human and mouse ALL cells migrated toward adipocyte conditioned media, which was mediated by SDF-1α. In addition, adipose tissue explants protected ALL cells against daunorubicin and vincristine. Our findings suggest that ALL migration into adipose tissue could contribute to drug resistance and potentially relapse.
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Authors
Rocky Pramanik, Xia Sheng, Brian Ichihara, Nora Heisterkamp, Steven D. Mittelman,