| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10909047 | Leukemia Research | 2013 | 5 Pages |
Abstract
In order to determine the relationship between expression of cyclic nucleotide phosphodiesterase isoform 7B (PDE7B) and mantle cell lymphoma (MCL) progression, PDE7B mRNA expression was measured by qRT-PCR in 21 untreated MCL patients with bone marrow involvement and 20 healthy donors. The expression level of PDE7B was markedly higher in MCL patients compared with normal controls (PÂ =Â 0.001), and the higher level of PDE7B expression was associated with unfavorable cytogenetic characteristics in MCL. It was showed that higher expression of PDE7B might be a novel unfavorable prognostic indicator in MCL, which possess important clinical significance.
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Authors
Cheng Fang, Hua-Jie Dong, Zhi-Jian Zou, Lei Fan, Li Wang, Run Zhang, Ji Xu, Wei Xu, Jian-Yong Li,