Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909048 | Leukemia Research | 2013 | 6 Pages |
Abstract
The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4+ and CD8+ lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8+ cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS.
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Authors
Matheus Rodrigues Lopes, Fabiola Traina, Paula de Melo Campos, João Kleber Novais Pereira, João Agostinho Machado-Neto, Helymar da Costa Machado, Simone Cristina Olenscki Gilli, Sara Teresinha Olalla Saad, Patricia Favaro,