Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909070 | Leukemia Research | 2012 | 4 Pages |
Abstract
We report eight patients of myelodysplastic syndrome (MDS) with HIV infection. Compared to a historical cohort of HIV-uninfected MDS patients, HIV/MDS were younger (p = 0.019), had more complex cytogenetics (p = 0.015), and more often had 7q deletion or monosomy 7 (p = 0.011). In five patients, HIV/MDS transformed to acute myeloid leukemia, with a median time to transformation of 7 months. Also, the median overall survival was shorter in the HIV/MDS than in their HIV-uninfected counterparts (8 vs. 22 months; p = 0.003). These results suggest that HIV/MDS is a high-risk MDS necessitating thorough cytogenetic analysis and follow-up.
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Authors
Koichi Takahashi, Mariko Yabe, Ilan Shapira, Sherry Pierce, Guillermo Garcia-Manero, Mala Varma,