Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909073 | Leukemia Research | 2012 | 5 Pages |
Abstract
Various gene mutations have been reported in patients with myelodysplastic syndrome (MDS). Serial studies of mutations during follow-up are important for investigating the stability of the mutations for use as minimal residual disease (MRD) markers. Sequential quantitative analyses of 5 patients with spliceosome-related gene mutations by allele-specific quantitative polymerase chain reaction revealed that the U2AF1 S34F and SF3B1 K666N were persistently retained during the disease progression. The spliceosome-related gene mutations appear to be stable during disease progression and may be useful as potential markers for MRD monitoring in MDS patients that usually lack established specific MRD markers.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Kazuyuki Matsuda, Fumihiro Ishida, Toshiro Ito, Hideyuki Nakazawa, Shuhei Miura, Chiaki Taira, Akane Sueki, Yukihiro Kobayashi, Takayuki Honda,