Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909074 | Leukemia Research | 2012 | 5 Pages |
Abstract
We treated individuals for disseminated intravascular coagulation (DIC) caused by acute promyelocytic leukemia (APL) (n = 9) using human soluble thrombomodulin (rTM) in combination with all-trans retinoic acid (ATRA) and chemotherapy, and compared the clinical outcomes with historical control patients (n = 8) treated with ATRA and/or chemotherapy. Two control patients developed intracranial vascular incidents. On the other hand, no bleeding related mortality was noted in rTM-treated patients. Notably, treatment with rTM rescued patients from DIC earlier than historical controls (log rank test, p = 0.019). These results suggest that administration of rTM should be considered for the treatment of individuals with DIC associated with APL.
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Authors
Takayuki Ikezoe, Asako Takeuchi, Mayuka Isaka, Yu Arakawa, Naomi Iwabu, Tsukie Kin, Kazuki Anabuki, Mizu Sakai, Ayuko Taniguchi, Kazuto Togitani, Akihito Yokoyama,