Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909093 | Leukemia Research | 2013 | 7 Pages |
Abstract
We present a molecular cytogenetic study of 8 mantle cell lymphoma (MCL) cell lines and 23 patients with MCL to determine and characterize novel secondary aberrations. We detected new secondary recurrent rearrangements in all cell lines and in 7 patients and confirmed 5p15.33 as a recurrent breakpoint in 4 cell lines and one patient. Further molecular characterization by flow-FISH and quantitative RT-PCR suggest TERT and CLPTM1L as target genes of 5p15.33 rearrangements.
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Authors
Georgia Schilling, Eva Maria Murga Penas, Snjezana Janjetovic, Leticia Oliveira-Ferrer, Melanie Braig, Petra Behrmann, Carsten Bokemeyer, Judith Dierlamm,