Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909096 | Leukemia Research | 2013 | 5 Pages |
Abstract
Given evidence for the role of Src family kinases, especially Lyn kinase, in myeloblast proliferation and the in vitro inhibitory activity of dasatinib on Src and Lyn, we conducted a phase II study to assess overall response to 100Â mg/day dasatinib in patients with higher-risk myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia, or acute myeloid leukemia arising from MDS and who had failed prior treatment with azanucleoside analogs. Among 18 patients treated, 3 responded, 4 had stable disease, and 10 experienced disease progression. Toxicities were limited and consistent with previous reports. Dasatinib appears to be safe but with limited efficacy.
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Authors
Vu H. Duong, Michael V. Jaglal, Ling Zhang, Vishakha Kale, Jeffrey E. Lancet, Rami S. Komrokji, Alan F. List,