Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909098 | Leukemia Research | 2013 | 8 Pages |
Abstract
We have previously demonstrated that two prognostic features of myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML), mutant NRAS and over-expressing BCL-2, cooperate physically and functionally in vivo. Screening of MDS patient bone marrow (BM) identified NRAS:BCL-2 co-localization in 64% cases, correlating with percentage BM blasts, apoptotic features and disease status (p < 0.0001). Localization of the complex at the plasma membrane or the mitochondria correlated with disease and apoptosis features in MDS patients, whilst caspase-9 mediated mechanism was elucidated in vivo and in vitro. The intensity and localization of the RAS:BCL-2 complex merits further evaluation as a novel biomarker of MDS.
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Authors
Carole Le Pogam, Patricia Krief, Stephanie Beurlet, Annie Soulié, Nicole Balitrand, Bruno Cassinat, Helene Cavé, Olivier Kosmider, Niclas Setterblad, Christophe Leboeuf, Laure Sarda-Mantel, Florence Hervatin, Pascal Merlet, Maria-Elena Noguera,