Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909119 | Leukemia Research | 2012 | 6 Pages |
Abstract
Genetic changes in T-ALL are classified into type A abnormalities leading to arrest at a specific stage of T-cell differentiation and type B abnormalities that target cellular processes including cell cycle regulation. Mutations and deletion of a BCL11B haploinsuffiecient tumor suppressor allele have been found in 10-16% of T-ALL subgroups. Analysis of Bcl11bKO/+ mice revealed impaired T-cell differentiation at two different stages and attenuation of γ-ray induced cell-cycle arrest at S/G2/M phase in immature CD8 single positive cells. Hence, those phenotypes provided by loss of a Bcl11b allele favor that Bcl11b mutation belongs to type B abnormalities.
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Authors
Rieka Go, Kazuyoshi Takizawa, Satoshi Hirose, Yoshinori Katsuragi, Yutaka Aoyagi, Yukio Mishima, Ryo Kominami,