Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909181 | Leukemia Research | 2012 | 6 Pages |
Abstract
The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology.
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Authors
Jaqueline Carvalho de Oliveira, Carlos Alberto Scrideli, MarÃa Sol Brassesco, Andressa Gois Morales, Julia Alejandra Pezuk, Rosane de Paula Queiroz, José Andres Yunes, Silvia Regina Brandalise, Luiz Gonzaga Tone,