Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909223 | Leukemia Research | 2012 | 4 Pages |
Abstract
MicroRNAs can influence hematopoietic cell lineage commitment and aberrant expression of hematopoietic miRNAs contributes to AML pathology. We found that miR-143 and miR-145 expression is significantly repressed in primary AML patient samples as compared to neutrophils of healthy donors. Further analysis revealed impaired neutrophil differentiation of APL cells upon inhibition of miR-145 expression. Lastly, we identified p73 as transcriptional regulator of miR-143/145 during neutrophil differentiation of APL cells. Our data suggest that low miR-145 levels in APL, possibly due to aberrant expression of p73 transcription factors, contribute to the differentiation block seen in this disease.
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Authors
Jasmin Batliner, Emanuel Buehrer, Martin F. Fey, Mario P. Tschan,